β-内啡肽及其抗血清对新生大鼠缺氧性脑水肿的影响

›› 1995, Vol. 15 ›› Issue (2): 69-71.

β-内啡肽及其抗血清对新生大鼠缺氧性脑水肿的影响

1.南京军区福州总医院；2.第二军医大学

收稿日期:1994-02-24 出版日期:1995-01-25 发布日期:2013-03-19

Effects of Beta-Endorphin and Antiserum on Hypoxic Encephaledema in Neonatal Rats

1.Fuzhou General Hospital of Nanjing Command, Fuzhou 350001；2.Department of Neurobiology, The Second Military Medical University

Received:1994-02-24 Online:1995-01-25 Published:2013-03-19

摘要/Abstract

摘要： 通过结扎7日龄大鼠右侧颈总动脉合并高温低氧环境制备新生鼠缺氧缺血性脑损伤动物模型，观察新生鼠缺氧缺血性脑损伤时β-内啡肽（β-EP）与脑水肿的关系及给予β-EP或β-EP抗血清对脑水肿的影响。结果表明，外源性β-EP可使脑水肿明显加重，而给予β-EP抗血清则使脑水肿明显减轻。提示β-EP可能是新生大鼠缺氧缺血性脑损伤时引起脑水肿的病理“介质”之一，过量的β-EP有加重脑水肿的作用。

关键词: &beta, -内啡肽, 新生大鼠, 缺氧缺血, 脑水肿

Abstract: The rat model of perinatal cerebral hypoxia-ischemia was prepared by permanent ligation of right common carotid artery combined with a temporary systemic hypoxic (inhaling 8% O₂+92% N₂) at 37℃ in 7-day-old SD rats. The relationship between beta-endorphin and encephaledema was observed in the established models. The encephaledema was deteriorated after the injection of beta-endorphin into cerebellomedullary cistern, while it was alleviated by the injection of beta-endorphin antiserum. It is suggested that beta-endorphin might play a role in the formation of encephaledema induced by cerebral hypoxic-ischemic injury in neonatal rats and plethoric beta-endorphin will aggravate encephaledema.

Key words: Beta-endorphin, Antiserum, Neonatal rat, Cerebral hypoxic-ischemia, Encephaledema

卢晓欣1, 陈新民1, 洪新如2, 王成海2. β-内啡肽及其抗血清对新生大鼠缺氧性脑水肿的影响[J]. , 1995, 15(2): 69-71.

LU Xiao-Xin-1, CHEN Xin-Min-1, HONG Xin-Ru-2, WANG Cheng-Hai-2. Effects of Beta-Endorphin and Antiserum on Hypoxic Encephaledema in Neonatal Rats[J]. , 1995, 15(2): 69-71.

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