实验动物与比较医学 ›› 1994, Vol. 14 ›› Issue (2): 63-66.

• 论文 •    

犬肠缺血——再灌流后血液及组织内超氧化物歧化酶的改变

  

  1. 中国人民解放军304医院

The Changes of Superoxide Dismutase Contents in Blood and Tissues after the Injury of Bowel Ischemia and Reperfusion in Dogs

  1. 304th Hospital of PL A, Beijing 100037

摘要: 用饲菌加肠系膜上动脉不全阻断的方法,观察实验大肠缺血—再灌流所导致的肝、肺功能改变与全血及组织内超氧化物歧化酶(SOD)含量的关系。结果发现,犬肠缺血——再灌流后血液及肺、肝组织内SOD含量明显下降并伴有肺、肝功能的明显损害。这提示,肠缺血——再灌流导致了机体氧化能力的明显下降,其肝、肺功能的损伤程度与其组织内SOD的下降水平有关。

Abstract: The portal circulation was reduced by partial occlusion of the superior mesen-tcric artery, and the consequent influences on superoxide dismutase (SOD) and or-gans functions were studied.The results showed that there was a marked reduction in SOD contents in the liver, lung and blood accompanics by the functional impai-rment of the organs damage after ischemia and reperfusion.