›› 1993, Vol. 13 ›› Issue (4): 208-210.

• 论文 • 上一篇    下一篇

乙醇对大鼠肝脏γ谷氨酰转肽酶活性的影响

  

  1. 1.河北省医学科学院;2.河北医学院
  • 收稿日期:1993-06-23 出版日期:1993-01-25 发布日期:2013-03-21

Effects of Chronic Alcohol Intake on Y-Glutamyl Transpeptidase Activity of Rat Liver

  1. 1.Hebei Academy of Medical Sciences,Shijiazhuang 050021;2.Hebei Medical College
  • Received:1993-06-23 Online:1993-01-25 Published:2013-03-21

摘要: 应用SD大鼠,观察了连续3个月饲喂小剂量乙醇对肝脏γ谷氨酰转肽酶(γ-GT)活性的影响,及试管内乙醇(最终浓度从34mmol/L到170mmol/L)对γ-GT纯酶活性的抑制作用。结果表明:整体实验中乙醇对肝脏γ-GT活性无明显影响,离体实验中乙醇对γ-GT活性有轻度的抑制作用,且随乙醇浓度的增加呈渐增趋势。

关键词: 乙醇, 肝脏, &gamma, 谷氨酰转肽酶, 大鼠

Abstract: To study the effects of chronic alcohol intake on γ-glutamyl transpeptidase (γ-GT)activity in rat liver. Male and female Sprague Dawley rats were fed with 20% ethanol at the dose of 790 mg/kg body weight per day for 3 months. The γ-GT activity was measured at 1,2,and 3 month of experiment. No significant differences were found in γ-GT activity between experimental and control rats, however γ-GT activity was inhibited by ethanol in vitro.

Key words: Alcohol intake, Rat liver, γ-Glutamyl, transpeptidase