一种新的实验性急性肾功能衰竭动物模型的研究

实验动物与比较医学 ›› 1991, Vol. 11 ›› Issue (4): 216-219.

一种新的实验性急性肾功能衰竭动物模型的研究

北京军事医学科学院放射医学研究所

收稿日期:1989-09-15 出版日期:1991-01-25 发布日期:2013-03-21

"A NEW EXPERIMENTAL ACUTE RENAL FAILURE MODEL "

Academy of millitary medical science, Institute of radiation medical science, Beijing

Received:1989-09-15 Published:1991-01-25 Online:2013-03-21

摘要/Abstract

摘要： 观察了大鼠左肾动脉注射油酸后肾微循环及实质细胞的改变。注射油酸后，肾内脉动血管弹性降低，紧张度增加，肾组织血液灌流量降低，肾小球及小管周围毛细血管内皮细胞肿胀、坏死，肾组织不需辅酶的脱氢酶减少，肾小管坏死，血清尿素氮升高。这些结果说明，大鼠左肾动脉注射油酸可引起急性肾功能衰竭（ARF），可用来模似人类的起源于肾微循境障碍的缺血性APF。

关键词: 微循环, 急性肾功能衰竭, 油酸

Abstract: "An experimental model of acute renal failure (ARF) has been developed by injection of oleic acid to left renal artery of rat. The changes of microcirculation and parenchyma cells of rat kidney were observed at 10 minutes, 6 and 24 hours after the injection. Following the injection, the elasticity of renal pulsing blood vessels became weaker and tense was elevated, renal tissue blood flow remarkably decreased, the severe edema and necrosis of renal microvessel endothelium cells were found, TTC staining occurcd intensive positive, tubular necrosis, BUN was significantly elevated. These results demonstrated that an experimental model of ARF in rat could be induced by injection of oleic acid to left renal artery. Tbis model was chara-cterized by the disturbance of kidney microcirculation. "

Key words: Acute renal failure, microcirculation, oleic acid

吴广礼,田牛. 一种新的实验性急性肾功能衰竭动物模型的研究[J]. 实验动物与比较医学, 1991, 11(4): 216-219.

WU Guang-Li,TIAN Niu. "A NEW EXPERIMENTAL ACUTE RENAL FAILURE MODEL "[J]. Laboratory Animal and Comparative Medicine, 1991, 11(4): 216-219.

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