动物活体淋巴系统99mTc-DX显像的实验研究

›› 1991, Vol. 11 ›› Issue (1): 11-13.

动物活体淋巴系统99^mTc-DX显像的实验研究

1.上海医科大学实验动物部；2.药学院物化教研室；3.华山医院核放射科

收稿日期:1990-09-23 出版日期:1991-01-25 发布日期:2013-03-21

STUDIES OF 99 ^MTc-DX IN ANIMAL SCINTIGRAPHY

Department of Laboratory Animal Science, Faculty of physicochemistry, Faculty of Nuclear Medicine in Huasan Hospital, Shanghai Medical University，Shanghai

Received:1990-09-23 Online:1991-01-25 Published:2013-03-21

摘要/Abstract

摘要： 应用自己研制的99^mTc—DX淋巴管显像药盒，对不同处理的动物进行了病理与显像结果分析。选用DX分子量为48，000。注射剂量0.1ml，放射强度0.5mci。大鼠注射尾静脉，小鼠于趾间皮下注射。用单光子发射计算机断层仪（SPECT）分别观察显像情况，并进行病理对比。结果表明：大鼠尾静脉注射后，肝、肾显像清晰。正常小鼠显像淋巴链完整，影像对称；患瘤小鼠局部淋巴通常受阻，淋巴链不完整，影像两侧不对称。显像结果与病理观察相同。研究结果提示：99^mTc—DX药盒除适用于临床推广应用外，还适用于实验动物肿瘤模型的诊断、肿瘤淋巴转移的预测、肿瘤术后的观察及肝癌导向治疗等实验研究。

Abstract: "We observed image state of the rats and mice with 99 ^mTc-DX that were made by ourself. The usefulness of 99 ^mTc-Dextran with a molecular weight of 48,000，injection size of 0.1 ml(0.2～0.5 mci) .Rat injected site from the tail vein, mice injected site from the skin of hind or front interdigits, the animal observed imaging with SPECT. The results yielded high-quality scintigraphy of the liver, kidney in rat and radionuclide of the mouse. We conclude that 99 ^mTc-DX is a very promising agent for lymphoscintigraphy. Animals as well as pilot studies in man produced high-contrast images of the lymph system. The potential value of this new radiopharmaceutical for diagnosis and follow-up of animal with cancer, cancer lymph metastasis, and animal laboratory studies of targeting therapy on liver cancer. "

Key words: 99 ^mTc-DX, Lymphoscintigraphy, Targeting therapy

周光兴, 陆维跃, 杨俊华, 潘俊, 李明, 赵为之. 动物活体淋巴系统99^mTc-DX显像的实验研究[J]. , 1991, 11(1): 11-13.

ZHOU Guang-Xing, LU Wei-Yue, YANG Jun-Hua, PAN Jun, LI Ming, ZHAO Wei-Zhi. STUDIES OF 99 ^MTc-DX IN ANIMAL SCINTIGRAPHY[J]. , 1991, 11(1): 11-13.