关键词: 远交群小鼠, 遗传控制, 遗传监测, 表型频率, 基因频率, 多态型

Abstract: "The genetic character of two colonies of ICR outbred mice and one colony of KM outbred mice in Shanghai area was studied by authors using biochemical markers and Ouchterlony methods. The phenotypes of 120 mice in l0 loci were tested, then the phenotype frequency and gene frequency in each colony were calculated. The results of comparative studies showed； (1) in eight loci, there are quite different phenotype frequency and gene frequency between two ICR colonies, especially in Es-3, Gpd-l, He and Idh-1 loci;(2) KM colony has six kinds of phenotype in Es-3 locus and polymorphism is the strain character of KM mice. In six loci (Car-2. Es-3, Gpd-1, Hbb, Idh-l and Mod-1), the gene frequency of KM colony approaches ICR colony Ⅱ; (3) in Es-3, Hbb, Hc, Idh-1, and Mod-1 loci, ICR colony I approaches the control substrain Jct： ICR； but in Gpd-1 locus, JcL:ICR js aproached by ICR colony Ⅱ: in Car-2 locus, Jcl: ICR has its own character. The relationship between the histories of ICR, KM mice and their geneic character was discussed. Authors have indicated the importance of genetic control in reproduction of outbred mice."