Table of Content

25 August 1991, Volume 11 Issue 4

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ORIENT HAMSTER AND ITS ANTISCHISTOSOMA CHARACTERS

ZHU Guo-Zheng, WANG Ying-Hua, LEI Guan-Yu, LIU Rui-San

1991, 11(4):  193-198. 

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Orient Hamster, Microtus fortis, is a wild rodent inhabited around Dongting Lake, Hunan Province. It was the only one species of rodents which resisted Schistosoma japanica infestation. Our work reveals that this hamster can raising and reproduce in the laboratory circumstance and either the captive wild Orient Hamster or the laboratory raised ones do have some characters of anti-Schistosoma infestation phenomenon

THE EFFECT OF AMMONIA ON RAT'S RESPIRATORY ORGANS

ZHANG Fan, YANG You-Ming, CHENG Hong

1991, 11(4):  208-211. 

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The purpose of this study was to determine the effect of ammonia gas for respiratory organs of rats at various concentrations and exposure duration. Meanwhile, the exposure conditions were evaluated when isolators were used as the inhalation exposure equipments. 120 rats were divided into five groups randomly. One group was used as control and the others were exposed to ammonia at 10, 20，40 and 170 ppm respectively. The respiratory organs were sampled for histopathological study on 30，55， and 108 days post exposure. The result showed that histopathological changcs were found in rats that had been exposed to 170 ppm NH3 after 30 days, such as severe loss of cilia， squamous metaplasia, ulceration and necrosis with variable inflammation of the subepithelial tissue in upper respiratory tract, exudate in the nasal passage. Noticeable lesion in upper respiratory tract，especially in nasal cavity, were seen in rats exposed to ammonia at 20 ppm for 108 days. No changes were found in other examinations at this concentration. When the ammonia concentration was 10 ppm, no effects were observed in rats exposed for 108 days. Therefore, the effects of ammonia at 20 ppm and histopathological changes in the nasal of rats was the most sensitive indicator for ammonia at low concentration.

"A NEW EXPERIMENTAL ACUTE RENAL FAILURE MODEL "

WU Guang-Li, TIAN Niu

1991, 11(4):  216-219. 

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"An experimental model of acute renal failure (ARF) has been developed by injection of oleic acid to left renal artery of rat. The changes of microcirculation and parenchyma cells of rat kidney were observed at 10 minutes, 6 and 24 hours after the injection. Following the injection, the elasticity of renal pulsing blood vessels became weaker and tense was elevated, renal tissue blood flow remarkably decreased, the severe edema and necrosis of renal microvessel endothelium cells were found, TTC staining occurcd intensive positive, tubular necrosis, BUN was significantly elevated. These results demonstrated that an experimental model of ARF in rat could be induced by injection of oleic acid to left renal artery. Tbis model was chara-cterized by the disturbance of kidney microcirculation. "

THE APPLICATION OF NON-LINEAR EQUATION IN THE STUDY OF GROWTH CURVES OF CHINESE KUN MING MOUSE

WU Gui-Lin-1, XU Jing-1, MA Li-1, WANG Long-1, YANG Ning-2

1991, 11(4):  220-222. 

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Three non-linear equations： Gompertz equation、kogistic equation and Richards equation were used to study growth curves of Chinese KM mouse. It was found that all of the three equations can simulate the growth process of KM mouse very well. Comparably speaking，the Gompertz equation is more suitable for studying growth curve than the others.