The Protective Effect of Oxymatrine on Asthma Mice

doi:10.3969/j.issn.1674-5817.2017.04.013

Abstract

Abstract: Objective To study the protective effect of Oxymatrine (OMT) on asthma mice. Methods The asthmatic BALB/c mice were induced by ovalbumin (OVA) and aluminium hydroxide.The general situations and weights of mice were observed every day. Then these mice were treated by using OMT and/or dexamethasone and were sacrificed at 5 or 15 days after treatment. The bronchoalveolar lavage fluid (BALF) and lung tissue of mice were obtained. Their pathological reaction was observed through HE stain. The total number of cells and eosinophilscells in BALF were counted. Result OMT can improve the weights of asthma mice. On day 5 and 15, the pathological reactions of the lung tissue in each treatment groups were the same with that of the asthma group, but the number of inflammatory cells in lung tissue was much less than that of the asthma group. The total number of cells and eosinophils cells in BALF were reduced compared with the asthma group (P<0.05 or P<0.01). Conclusion OMT has protective effect on the asthma mice.

Key words: Oxymatrine(OMT), Asthma, Pathological changes, Protection, Mice

CLC Number:

Q95-33

LAN Lu-sha, ZHAO Bing-bing, YANG Hong-yu, LUO Hong, JIANG Yan. The Protective Effect of Oxymatrine on Asthma Mice[J]. Laboratory Animal and Comparative Medicine, 2017, 37(4): 320-323.

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