Abstract: Objective To establish the endometriosis models in rats. Methods Twenty-six mature female SD rats were used. The rat endometriosis model was established by autotransplantation with uterine tissues. Eight weeks after the autotransplantation,the second laparotomy was performed for observing the size,conglutination and pathological changes of the autotransplants. Results Saccate autotransplants were found in twenty-one rats, all of which were embedded in the peripheral tissues. The morphology and structure of most ectopic endometrium were as same as the eutopic endometrium, though there were less epithelium and stroma in ectopic tissues. However, in a few cases, there was either epithelium or stroma. Conclusion The endometriosis model established is successful, which can provide an ideal model for further study of the mechanism and medical treatment of endometriosis.

Key words: Endometriosis, Disease model, Rat