Research Progress on Toxic Milk Mouse

doi:10.3969/j.issn.1674-5817.2016.06.014

Abstract

Abstract: Toxic milk mouse is mutant a strain that produced by DL mice at F68. The main pathological shows are low pigmentation, growth retardation, tremor and movement disturbance. The common ground with Wilson disease are autosomal recessive inheritance, and large quantities of copper deposit in adult mouse that lead the levels of serum copper and serum ceruloplasmin protein declined. This paper reviews the researches on Toxic milk from several aspects, including pathophysiology, disease mechanism, diagnostics and therapy.

Key words: Toxic milk mouse, Accumulation of copper, Protein ATP7B

CLC Number:

Q95-33

ZHANG Wei,TANG Bin,LI Fu-rong. Research Progress on Toxic Milk Mouse[J]. Laboratory Animal and Comparative Medicine, 2016, 36(6): 473-478. DOI: 10.3969/j.issn.1674-5817.2016.06.014.

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