Comparison on Anesthetic Effect of Intravenous Pentobarbital Sodium or Isoflurane Anesthesia in Mini-pig

doi:10.3969/j.issn.1674-5817.2013.03.012

Abstract

Abstract: Objective To observe the anesthetic effect of pentobarbital sodium iv or isoflurane anesthesia on mini-pig. Methods A total of 10 healthy Bama mini-pigs were equally randomized into two groups. One group was administered with pentobarbital sodium intravenously,and the other group was administered with isoflurane . Changes in narcotic indicators were observed. Results There was no significant difference in the number, body weight, anesthesia performing hours, the adverse reaction rate, SPO₂and pH value between the two groups (P>0.05), but both groups had significant difference in the onset time of anesthesia, postoperative recovery time, the number of cases of intraoperative restlessness, MAP and HR (P<0.05) between the two groups. Conclusion Anesthetic dose of sodium pentobarbital needs to be added during the experiment, while isoflurane anesthesia has better postoperative analgesic effect and less side effects, being a safe and effective analgesic option for different experiments.

Key words: Intravenous anesthesia, Inhalational anesthesia, Mini pig

CLC Number:

Q95-33

CAI Li-ping,YU Chen-lin,ZHAO Shan-min,et al. Comparison on Anesthetic Effect of Intravenous Pentobarbital Sodium or Isoflurane Anesthesia in Mini-pig[J]. Laboratory Animal and Comparative Medicine, 2013, 33(3): 222-224. DOI: 10.3969/j.issn.1674-5817.2013.03.012.

References

[1] 汤球, 刘志学, 余琛琳, 等. 小型猪腹壁拉链模型的建立及其在外科教学中的应用研究[J]. 实验动物与比较医学. 2012, 32(2):137-141.
[2] Jewell C, Ackermann C, Payne NA, et al.Specificity of procaine and ester hydrolysis by human, minipig,and rat skin and liver[J]. Drug Metab Dispos, 2007, 35:2015-2022.
[3] Yabuki A, Kamimura R, Setoyama K, et al.Skin morphology of the Clawn miniature pig[J]. 2007, 56:369-373.
[4] 邱波, 王艳, 胡健廷, 等. SD大鼠与巴马小型猪的皮肤组织学比较[J]. 中国比较医学杂志. 2012, 22(6):14-15,20.
[5] Stamphl U, Radeleff B, Sommer C, et al.Paclitaxel-induced arterial wall toxicity and inflammation:part 2-long-termtissue response in a minipig model[J]. J Vasc Interv Radiol, 2009, 20(12):1608-1616.
[6] 刘宇, 魏泓. 小型猪心血管系统疾病动物模型研究现状及趋势[J]. 实验动物与比较医学. 2011, 31(5):322-329.
[7] 莫安胜, 张帆, 贺榜福, 等. 广西巴马小型猪标准原位心脏移植模型的建立[J]. 中华器官移植杂志. 2009, 30(11):697-698.
[8] 汤球, 刘志学, 余琛琳, 等. 小型猪腹壁拉链模型评价指标体系的建立[J]. 实验动物与比较医学, 2011, 31(3):178-182.
[9] 余琛琳, 汤球, 刘志学, 等. 小型猪腹壁拉链动物模型应用于实验动物学教学中的体会[J]. 医学研究杂志, 2010, 39:118-119.
[10] 刘忠慧, 郝子悦. 猪外科手术中麻醉方法的研究[J]. 黑龙江动物繁殖, 2009, 17:3-4.
[11] 蔡丽萍, 余琛琳, 徐晨. 金霉素改善小型猪腹壁拉链动物模型术部疗效观察[J]. 实验动物与比较医学, 2012, 32(6):531-533.
[12] 王洋, 王承利, 张贺. 异氟醚吸入麻醉在巴马小型猪中的应用[J]. 中国比较医学杂志, 2010, 20(10):38-40.
[13] 王凯, 黄丽洁, 苟鹏, 等. 腹部手术中两种麻醉方法对幼龄小型猪麻醉效果比较[J].实验动物科学, 2010, 27(5):37-39,44.
[14] 王凯, 黄丽洁, 苟鹏, 等. 小型猪的麻醉及气管插管技术[J].实验动物科学, 2011, 28(1):49-51.

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