Abstract: Objective To study the 1 -Bromopropane (1-BF) induced toxic effects in F344/NSIc rat and Wistar NWN rat. Methods Six male Wistar NWN and six male F344/NSIc rats were exposed to 5030 mg/m3 1-bromopropane by inhalation for continuously 1 week. Animals were sacrificed，and the testes and posterior tibial nerve were dissected for histopathological examination, either stained by periodic acid-Schiff staining method or stained by Kliiver-Barrera staining method. Results Testicular histopathology showed that retained, enlongated sperms were found in the seminiferous epithelium (stage VIII) in both strains, which indicated the spermiation failure. Pathology of posterior tibial nerve showed that ovoid or bubble-like debris of myelin sheath was also found in both F344/NSIc and Wistar NWN rats. Conclusion The typical pathological change of 1 -BP induced toxicity can be reproduced in both F344/NSIc and Wistar NWN rats. F344/NSIc in-bred rat is the suitable strain for studying the toxic effects of 1-BP at gene level.

Key words: F344/NSIc rat, Wistar NWN rat, 1-bromopropane, Toxicity, Histopathology