Abstract: Objective To investigate the change rules of the body temperature in conventional Japanese white rabbits and New Zealand rabbits under physiological condition. Methods In the environment of 23.5-28 ℃ and relative humidity 54%-65%, the body temperature of rabbits in free stateus were determined continuously by using TOSHONG wireless automatic temperature measurement platform. The 12 480 points of rabbits’ temperature picked from 312 000 times of measurements were analysed. Results Feeding the rabbits quantitatively in the same time in morning and evening, the tested animals’ circadian body temperature is the W type. 1∶00-6∶00, 15∶00-18∶00 are the rise period of temperature, 7∶00-11∶00, 20∶00-0∶00 are the descend period of temperature, 5∶00-8∶00, 18∶00-20∶00 are the peak of temperature, 23∶00-2∶00, 11∶00-15∶00 are the trough of temperature. The rabbits’ body temperature changes bigger than usual in the next 5 hours after they eating. Conclusions The rabbits’ body temperature showed downtrend in the next 2-5 hours after they eating, 23∶00-2∶00, 11∶00-15∶00 are the trough of temperature. Pyrogen test is suitable for to taken in 0∶00-3∶00 and 12∶00-15∶00. The method which widely used in animal experiments according to the method of average 24 hours time interval measurement may be remained consultative.

Key words: Big data, Japanese white rabbit, New Zealand rabbit, Rule of body temperature period, Pyrogen test