Situation on Research of Murine Norovirus

doi:10.3969/j.issn.1674-5817.2014.02.019

Abstract

Abstract: Norwalk virus, also known as norovirus, is the major pathogen to cause human nonbacterial gastroenteritis, in addition, Norwalk virus is also found in cattle, pigs and mice . Norwalk virus can be divided into five genotypes (GI-V), and the murine norovirus (MNV) belongs to GV. MNV is a newly discovered virus infection in laboratory mice, and is considered to be the most popular form of mouse virus. Now, MNV is the only one that can be replicated efficiently in cells of the Norwalk virus, so MNV is regarded as a research model for the molecular mechanism of Norwalk virus. Moreover, MNV and human Norovirus (HuNV) have many similar characteristics of molecular biology, and also is considered to be the ideal virus model for study of human norovirus.

Key words: Murine norovirus(MNV), Biological characteristics, Epidemiology

CLC Number:

Q95-33

LIU Qin, WEI Xiao-feng, GAO Cheng. Situation on Research of Murine Norovirus[J]. Laboratory Animal and Comparative Medicine, 2014, 34(2): 167-170.

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