Effects of Shenqifuxin Oral Liquid on Plasma Kaliuretic Peptide, Myocardial Contractility and Relaxation of Left Ventricle in Rats after Sleep Deprivation

doi:10.3969/j.issn.1674-5817.2012.03.005

Abstract

Abstract: Objective To observe the effects of Shenqifuxin oral liquid (SQFXOL, 参芪扶心口服液) on plasma kaliuretic peptide (KP) and the left ventricular remodeling and the myocardial contractility and relaxation of left ventricle in rats after sleep deprivation. Methods The hemodynamic parameters were measured by the method of the catheterization. Plasma concentrations of KP, ANP, AngⅡ and ET-1 were determined by radioimmunoassays. Results In high dose group, the LVSP, dp/dtmax and Vmax were increased; LVEDP was decreased, plasma concentrations of KP, AngⅡ and ET-1 were decreased significantly(P<0.05 or P<0.01). The levels of plasma ANP in middle dose group and low dose group were significantly lower than those in model group (all P<0.01). Conclusion SQFXOL can reduce the plasma concentrations of KP, AngⅡ, ET-1, and ANP, improve the myocardial contractility and relaxation of left ventricular in rats with HF after myocardial infarction.

Key words: Shenqifuxin Oral Liquid, Sleep deprivation, Cardiac function, Kaliuretic peptide

CLC Number:

R338.8Q95-33

MA Lu, ZHU Xiao-fa, QIAN Yan-fang, LI Xiu-yu, ZHAO Mei-na. Effects of Shenqifuxin Oral Liquid on Plasma Kaliuretic Peptide, Myocardial Contractility and Relaxation of Left Ventricle in Rats after Sleep Deprivation[J]. Laboratory Animal and Comparative Medicine, 2012, 32(3): 195-198.

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