Effects of Corn Peptide and Aerobic Exercise on Levels of Glucagon、MCP-1、PP and PYY in Plasma of Obese Rats

doi:10.3969/j.issn.1674-5817.2014.03.009

Abstract

Abstract: Objective To investigate the effects of corn peptide and aerobic exercise on the Glucagon, MCP-1(monocyte chemoattractant protein -1), PP(Pancreatic polypeptide) and PYY (Peptide YY) plasma levels for analyzing the hormonal related regulation of the body weight lose in obese rats. Methods Fifteen male SD rats were randomly selected from 150 as normal diet group (C). The rats of C were given a normal diet , while the remaining 135 were given a high fat diet. 8 weeks later the 40 male obese rats were randomly divided into obesity control group (OC) , casein supplement group (Cas), corn peptide supplement group (CP) , obese rats exercise group (OE) and corn peptide supplement combined obese rats exercise group (OEC). OE and OEC group rats took aerobic exercise during 4 weeks intervention. ELISA method was used to test the Glucagon, MCP-1, PP and PYY levels in the rats plasma. Results Four weeks intervention later, the body weight of OC was significantly higher than C, and the body weight of OE and OEC group were significantly lower than OC. There was no significant difference between OC and C in Glucagon level, but the Glucagon level of CP was significantly lower than OC. The MCP-1 level in OC group was significantly higher than C. and compared with OC, the MCP-1 levels of CP, OE and OEC decreased significantly . The PYY levels of OC were significantly lower than C, the PYY level of OEC was significantly higher than OC and CP. There was no significant difference among all groups for PP plasm level. Conclusion Corn peptides can reduce the plasma levels of Glucagon and MCP-1 in obese rats. The aerobics combined with corn peptide supplyment can reduce the plasma level of MCP-1 and increase the plasma level of PYY in rats.

Key words: Corn peptide, Aerobic exercise, Glucagon, MCP-1, PP, PYY

CLC Number:

Q95-33

LI Xiang, SHI Reng-fei, LOU Shu-jie. Effects of Corn Peptide and Aerobic Exercise on Levels of Glucagon、MCP-1、PP and PYY in Plasma of Obese Rats[J]. Laboratory Animal and Comparative Medicine, 2014, 34(3): 214-218.

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