Laboratory Animal and Comparative Medicine ›› 2020, Vol. 40 ›› Issue (2): 141-143.DOI: 10.3969/j.issn.1674-5817.2020.02.009

Special Issue: 实验动物资源开发与利用

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Observation of Pulse Wave Velocity and Arterial Wall Structure in Spontaneously Hypertensive Rats at Different Ages

GUO Jing1, GU Wenyong1, WU Yongjie1,2   

  1. 1. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    2. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Shanghai 200025, China
  • Received:2019-11-23 Online:2020-04-25 Published:2020-12-18

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Abstract: Objective To reveal the physiological changes of blood vessels in different growth stages of spontaneous hypertensive rats (SHR) by measuring the pulse wave velocity (PWV) and analyzing the structure of aortic media cross-sectional area (MCSA) in the same period of SHR. Methods Color Doppler ultrasonography and vascular pathological analysis were used to determine PWV and MCSA of SHR at 4, 6, 8, 10 and 12 month of age. Results The PWV of 12-month-old SHR was significantly higher than that of 8-month-old, 6-month-old and 4-month-old SHR respectively(P<0.05). The PWV of 10-month-old SHR was significantly higher than that of 6-month-old and 4-month-old SHR respectively (P<0.05). Meanwhile, the MCSA analysis of SHR showed that the aortic MCSA of SHR increased gradually with age. Conclusion With the increase of age, the arterial compliance of SHR is worse, the vascular elasticity is decreased, and the degree of atherosclerosis is enhanced.

Key words: Spontaneous hypertensive rat, Pulse wave velocity, Media cross-sectional area

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