Abstract: Laboratory rabbit is an important species in laboratory animals, mainly used in pharmaceuticals,pyrogen testing of biotechnology products，the preparation of antiserum, skin irritation test，the optic nerve，microbiology，sports medicine and other scientific research and teaching fields. The requirement of laboratory rabbit is followed after the rats，mice，hamsters and guinea pigs. It is an irreplaceable experimental material and model. Research on breeding and application of SPF laboratory rabbit is rapid development in developed countries. With the development of China's life sciences and medical research，and for the request of the new “Chinese Pharmacopoeia” and “China Requirement Biological Products”，on the quality of laboratory rabbit，it was gradually moves closer to the Clean level and SPF level. This paper is an overview on the progress of the work for SPF rabbit breeding and biological characteristics in China.

Key words: SPF rabbits, Breeding, Biological characteristic, Research progress