Analysis of the Progress in Identification and Evaluation of Laboratory Animal Resources in China

doi:10.12300/j.issn.1674-5817.2024.050

Abstract

Abstract:

Laboratory animals are not only a national strategic resource but also an important support for development of science and technology. The Committee of Identification and Evaluation for Laboratory Animal Resources, organized by Chinese Association for Laboratory Animal Sciences and established in May 2019, is currently the only specialized academic agency dedicated to the identification and evaluation of laboratory animal resources in China. This paper first discusses the significance of identifying and evaluating laboratory animal resources, summarizes three new approaches to developing these resources, including the domestication and standardization of laboratory animals (economic, ornamental, agricultural, and wild animals, etc.), the acquisition of new strains (species) through natural mutation and induced mutation, and the creation of new laboratory animal resources through gene editing technology. It then introduces the workflow for resource identification and evaluation, including preliminary review (format review), written review (expert review), joint review or on-site inspection, final review (voting and public announcement)，and the issuance of certificates. The required materials to be submitted include application, summary report, research or identification reports, appendices and other necessary documents. The paper further discusses related requirements for resource identification and evaluation, including population, genetic classification, biological characteristics, genetic stability, and application value. Finally, the current status of newly identified laboratory animal strains (species) and issues in current work practices are analyzed, as well as solutions to these issues. This paper aims to provide a valuable reference for further research in this field.

Key words: Laboratory animal, Laboratory animal resources, Identification and evaluation

CLC Number:

Q95-33

DU Xiaoyan,LIU Yunbo. Analysis of the Progress in Identification and Evaluation of Laboratory Animal Resources in China[J]. Laboratory Animal and Comparative Medicine, 2024, 44(5): 469-474. DOI: 10.12300/j.issn.1674-5817.2024.050.

Figures/Tables 1

References 20

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开发途径 Development method	实验动物新资源的品种（系）名称 Strain name of new laboratory animal resource	申请单位 Applying institution	获批时间 Approval time
野生动物实验动物化 Laboratory animal from wild animal	长爪沙鼠脑缺血近交系	首都医科大学	2021年5月
	长爪沙鼠糖尿病近交系	首都医科大学	2021年5月
	洞庭湖东方田鼠	上海实验动物研究中心	2021年5月
家畜实验动物化 Laboratory animal from domestic animal	中畜五指山小型猪近交系	中国农业科学院北京畜牧兽医研究所	2022年9月
基因编辑或基因修饰 Gene editing or modification	人抗体转基因小鼠CAMouse^HG	重庆市畜牧科学院	2021年5月
	中农巴马小型猪ApoE基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	中农巴马小型猪LDLR基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	中农巴马小型猪ApoE和LDLR双基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	无αGal抗原基因编辑巴马小型猪（BGMP）品系	成都中科奥格生物科技有限公司	2023年9月
	B-NDG^®免疫缺陷小鼠	百奥赛图（北京）医药科技股份有限公司	2024年2月
	人源化ACE2基因敲入（hACE2-KI）的BALB/c 小鼠	中国人民解放军陆军军医大学	2024年7月
传统实验动物突变 Traditional laboratory animal mutation	白毛黑眼兔（WHBE）封闭群	浙江中医药大学	2023年9月

开发途径 Development method	实验动物新资源的品种（系）名称 Strain name of new laboratory animal resource	申请单位 Applying institution	获批时间 Approval time
野生动物实验动物化 Laboratory animal from wild animal	长爪沙鼠脑缺血近交系	首都医科大学	2021年5月
	长爪沙鼠糖尿病近交系	首都医科大学	2021年5月
	洞庭湖东方田鼠	上海实验动物研究中心	2021年5月
家畜实验动物化 Laboratory animal from domestic animal	中畜五指山小型猪近交系	中国农业科学院北京畜牧兽医研究所	2022年9月
基因编辑或基因修饰 Gene editing or modification	人抗体转基因小鼠CAMouse^HG	重庆市畜牧科学院	2021年5月
	中农巴马小型猪ApoE基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	中农巴马小型猪LDLR基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	中农巴马小型猪ApoE和LDLR双基因缺失品系	中国农业科学院农业基因组研究所	2022年11月
	无αGal抗原基因编辑巴马小型猪（BGMP）品系	成都中科奥格生物科技有限公司	2023年9月
	B-NDG^®免疫缺陷小鼠	百奥赛图（北京）医药科技股份有限公司	2024年2月
	人源化ACE2基因敲入（hACE2-KI）的BALB/c 小鼠	中国人民解放军陆军军医大学	2024年7月
传统实验动物突变 Traditional laboratory animal mutation	白毛黑眼兔（WHBE）封闭群	浙江中医药大学	2023年9月

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