Abstract: Objective To study the dysfunction of islets β cell in scalded rats with LPS-injected and. the effects of GIK(glucose-insulin- Potassium) treatment to the islets P cell. Methods Ninety SD scalded rats with LPS-injected were divided randomly into the S+LPS(n=30)，GIK (n=30) and control groups(n=30). The glucose and insulin of the fasting and 30min post of glucose injected of the all groups were determined, and the HOMA-β,△ INS30/△ GLU30 and HOMA-IR were calculated and observed. Results The glucose and insulin of the fasting and 30min post of glucose injected and the HOMA-IR of the S+LPS group were higher than that of the before scalded(P＜0.01), but the HOMA-β and △ INS30/△ GLU30 of the S+LPS group were lower than that of the before scalded(P＜0.01). The HOMA-β and △ INS30/△ GLU30 of the GIK group were higher than that of the control group, there was no difference of HOMA-TR significantly between the GIK and control group. Conclusion The serious burn rats represents dysfunction of early phase and basal insulin release of p cell, GIK treatment would be beneficial for the protect of β cell on this states.

Key words: Burn, Dysfunction of islets p-cell, GIK, Effect