Abstract: Objective To induce an impaired glucose and lipid metabolism model by high-glucose-fat feeding (HGF) plus DEX so as to facilitate type 2 diabetes study. Methods The model was induced by HGF and HGF plus DEX respectively in tree shrew. Fourteen normal male tree shrews were randomly divided into 2 groups: HGF group with 6 tree shrews and HGF plus DEX group with 8. Several param-eters in the tree shrews were measured. Results The fasting blood glucose，lipid level and OGTT significantly increased in HGF+DEX treated group compared with the HGF group while the fasting body weight reduced in both group. Conclusions High-glucose-fat feeding and DEX together can be used to induce glycometabolism and lipid metabolism abnormality.

Key words: Tree shrew, Impaired glucometabolism, Dexamethasone (DEX);High-glucose-fat feeding(HGF)