Abstract: It is a key step that Mammalian reovirus adhesion and entry into the host cells during the infection，including that the different domains on the outer capsid protein interact with the different receptors on the surface of host cells. There are three kinds of virus capsid protein ol，o3,and ul，playing important roles of the binding of reovirus to receptors oil the surface of host cells. The reovirus strains use Sialic Acid(SA), junctional adhesion Molecule-1, cell surface carbohydrate as the receptors，which could bind to the surface protein of the virus specifically and explain both cell-type specific tropism and broad hosts, thus, the research on the virus-receptor interactions are conducive to reveal the pathogenesis and replication. This review will summarize recent advances made in studies of reovirus outer capsid protein and Receptor.

Key words: Reovirus, Outer capsid protein, Receptor, Sialic acid, Junctional Adhesion Molecule-1