Human diabetic mellitus is the complicated metabolic disease, especially of non-insulin-dependent diabetes mellitus (NIDDM). Then the appropriate diabetic mellitus animal model is the important basic of research. There are many NIDDM animal models, such as experimental NIDDM animal model，spontaneous NIDDM animal model, transgenic NIDDM animal model and anti-insulin cell model for NIDDM, and so on. This mini-review mainly focused on the advances of the animal models, which from the pathogenesis and clinic symptom,and also the prospect was indicated.