Abstract: Objective To establish a My coplasm suis Kunming mouse model with blood from the My coplasm suis infected pigs to explore the laws，the occurrence and development and outcome, of this disease in rodents to reveal the pathogenic mechanism of Mycoplasma suis further. Methods The Kunming mouses were inoculated with blood from the Mycoplasm suis infected pigs, the rate of infection and histopathological changes were determined in different stages after challenge. Results The Kunming mouse model was established successfully and the tissues and organs of different infection stages were detected. It was demonstrated that different pathological changes were in different infection stages. Conclusion Investigating the rate of infection and histopathological changes of the Kunming mouse model is beneficial to reveal Mycoplasma suis pathogenic mechanism.

Key words: Mycoplasma suis, Mouse model, Pathological changes, Histopathology