Abstract: Objective To explore the effect on iron deficiency anemia rat model induced by 3 different formula feeds. Method Wistar rats at age of 3~4 weeks were randomly divided into 4 groups: group A, group B, group C and control group. The groups A, B, C were fed with 3 different formula feeds respectively, and control group was fed with normal feed. Experiment lasts for 35 days, the body weight and food intake of rats in each group were measured every week. Meanwhile, behavior and appearance sign was noted during the experiment. Rat抯 blood was collected and tested after 35 days, including hemoglobin, hematocrit, etc. Results Hemoglobin(Hb) concentration of group A decreased to 90 g/L and morphological features met the requirments. Hb in group B did not decrease; Hb in group C decreased a little but no less than 90 g/L. Conclusion The formular A feed can establish iron deficiency anemia model successfully, formula B and C are not applicable for the model building.

Key words: Iron deficiency anemia, Wistar rats, Hemoglobin(Hb)