Abstract: Objective To study the inhibiting effect of coix seed oil injection on human live cancer SMMC-7721 grafted in nude mice. Methods The model of human live cancer SMMC-7721 grafted in nude mice was established, the tumor size and body weight of mice bearing tumors were observed and measured, then relative tumor growth rates and tumor inhibition rates calculated. After the last treatment, tumors and various organs were harvested for immunohistochemistry and HE staining. Result The relative tumor growth rates of three dose groups of coix seed oil injection were 33.02%, 35.78% and 39.41%, and the inhibition rates were 49.54%, 46.86% and 41.71% respectively. The positive Ki-67 staining rate of tumors in nude mice treated with coix seed oil injection was significantly lower than that in the control group. Main organs showed normal state according to hematoxylin and eosin staining. Conclusion Coix seed oil injection has certain inhibition efficacy on the xenograft model of human liver cancer cell SMMC-7721.

Key words: Coix seed oil, SMMC-7721, Nude mice