The Effect of Epigalloca-techin-3-gallate(EGCG) on Expression of GLUT4 in Skeletal Muscle Tissue of Goto-kakizaki Rats

doi:10.3969/j.issn.1674-5817.2011.06.004

Abstract

Abstract: Objective To investigate the effect of epigalloca-techin-3-gallate(EGCG)on expression of GLUT4 in the skeletal muscle tissue of Goto-kakizaki rats. Methods Goto-kakizaki diabetic rats (GK, n=40) were observed and Wistar rat (n=10) as control. Rats were randomly divided into fIve groups: normal control group, TIIDM model group , diabetic model plus EGCG of 50mg/kg, 100mg/kg and 300mg/kg therapy group .After 6 weeks,blood glucose,serum lipids and the expression of GLUT4 were detected. Results EGCG obviously improved the OGTT and serum lipids, and increased the expression of GLUT4 in skeletal muscle membrane fraction. Conclusion EGCG can decrease the levels of blood glucose in type II diabetic rats, and its mechanisms might be closely related to the elevation of the level of GLUT4 in the skeletalmuscle tissues of rats.

Key words: Epigalloca-techin-3-gallate(EGCG), Goto-kakizaki rat, GLUT-4

CLC Number:

Q95-33

ZHAO Xian-zhe, ZHANG Jiang, QIAO Wei-wei, CHEN Li-xin, GU Jian-zhongzhong. The Effect of Epigalloca-techin-3-gallate(EGCG) on Expression of GLUT4 in Skeletal Muscle Tissue of Goto-kakizaki Rats[J]. Laboratory Animal and Comparative Medicine, 2011, 31(6): 418-421.

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