Analysis on Current Status and Countermeasures for Laboratory Animal Management in Sichuan Province Based on Administrative Licensing

doi:10.12300/j.issn.1674-5817.2024.055

Abstract

Abstract:

Laboratory animals are indispensable strategic resources that support technological progress and innovation. At the same time, the biosafety of laboratory animals is an important component of national public health security. The production and use of laboratory animals require statutory administrative licensing. This article first summarizes the current status of management and development in Sichuan Province by reviewing the number, types, and industry distribution of license-holding facilities, the area of facilities and the status of top ten largest facilities by area, the types and quantities of laboratory animals produced, and the production capacity of certain facilities, as well as the types and quantities of laboratory animals used and the status of the top ten facilities by animal quantity. Then, it discusses the development advantages of the laboratory animal industry in Sichuan Province, including its leading industrial scale in the western region, increasing regional influence, and emerging comprehensive benefits. However, there are significant issues such as the inability of laboratory animal production to adequately meet the demand, the need to improve the level of technological innovation, and the challenges of ensuring animal safety management. Finally, corresponding countermeasures suggestions are proposed, including actively supporting the improvement of quality and efficiency of laboratory animal production, establishing a stable support mechanism for technological innovation, and placing a strong emphasis on animals safety management. This article aims to provide a reference for further improving the management level and industry development momentum of laboratory animals in Sichuan Province and other provinces.

Key words: Laboratory animals, Administrative licensing, Sichuan Province, Development status, Management countermeasures

CLC Number:

Q95-33

CHEN Bing,ZOU Yixing,WANG Jingdong. Analysis on Current Status and Countermeasures for Laboratory Animal Management in Sichuan Province Based on Administrative Licensing[J]. Laboratory Animal and Comparative Medicine, 2024, 44(5): 560-566. DOI: 10.12300/j.issn.1674-5817.2024.055.

Figures/Tables 4

References 20

1	秦川, 孔琪, 钱军, 等. 实验动物科学技术是生命科学和健康中国建设的基础支撑条件[J]. 科技导报, 2017, 35(11):10-14. DOI: 10.3981/j.issn.1000-7857.2017.11.001 .
	QIN C, KONG Q, QIAN J, et al. Laboratory animal science and technology is strategically important to life science and health China construction[J]. Sci Technol Rev, 2017, 35(11):10-14. DOI: 10.3981/j.issn.1000-7857.2017.11.001 .
2	徐容, 曹入双, 杨茂, 等. 低碳水化合物饮食对小鼠肾脏和肝脏的影响[J]. 食品安全导刊, 2021, 7(27):91-94.
	XU R, CAO R S, YANG M, et al. Effects of Low-carbohydrate diet on kidney and liver of mice[J]. China Food Saf Mag, 2021, 7(27):91-94.
3	韦晓娟, 杨阳, 刘静. 可植入式温差发电技术的动物实验研究[J]. 北京生物医学工程, 2008, 27(3):276-280. DOI: 10.3969/j.issn.1002-3208.2008.03.014 .
	WEI X J, YANG Y, LIU J. Animal experiments on implanted thermal electricity generator[J]. Beijing Biomed Eng, 2008, 27(3):276-280. DOI: 10.3969/j.issn.1002-3208.2008.03.014 .
4	苏瑞军, 晋小婷, 安全, 等. 太原市冬季大气PM_2.5暴露对小鼠脏器及炎症因子的影响研究[J]. 环境与健康杂志, 2015, 32(8):677-679. DOI: 10.16241/j.cnki.1001-5914.2015.08.005 .
	SU R J, JIN X T, AN Q, et al. Effects of PM_2.5 collected in winter of Taiyuan on organs weights and inflammatory cytokines expressions in mice[J]. J Environ Health, 2015, 32(8):677-679. DOI: 10.16241/j.cnki.1001-5914.2015.08.005 .
5	董李晋川, 黄红, 刘斌, 等. 苏俄太空动物实验研究发展历程[J]. 中国实验动物学报, 2022, 30(4):557-567. DOI: 10.3969/j.issn.1005-4847.2022.04.015 .
	DONG L J C, HUANG H, LIU B, et al. A review of space animal experiments conducted by the former Soviet Union and Russia [J]. Acta Lab Animalis Sci Sin, 2022, 30(4):557-567. DOI: 10.3969/j.issn.1005-4847.2022.04.015 .
6	李晓波, 付瑞, 王洪, 等. 实验大鼠仙台病毒抗体检测能力验证结果评价[J]. 实验动物科学, 2017, 34(1):1-6. DOI: 10.3969/j.issn.1006-6179.2017.01.001 .
	LI X B, FU R, WANG H, et al. Laboratory proficiency testing for rat Sendai virus antibody detection[J]. Lab Anim Sci, 2017, 34(1):1-6. DOI: 10.3969/j.issn.1006-6179.2017.01.001 .
7	孔琪, 李继平, 赵永坤. 实验动物资源是生物医药产业创新的重要支撑条件[J]. 科技导报, 2016, 34(11):12-13.DOI:CNKI:SUN:KJDB.0.2016-11-009 .
	KONG Q, LI J P, ZHAO Y K. Experimental animal resources are an important supporting condition for the innovation of biomedical industry[J]. Sci Technol Rev, 2016, 34(11):12-13.DOI:CNKI:SUN:KJDB.0.2016-11-009 .
8	李根平, 赵德明. 北京地区实验动物法规建设与实验动物行业发展关系的研究[J]. 实验动物科学, 2008, 25(6):33-35, 38. DOI: 10.3969/j.issn.1006-6179.2008.06.009 .
	LI G P, ZHAO D M. Study on relationship between legislation making and industry development of Beijing laboratory animal[J]. Lab Anim Sci, 2008, 25(6):33-35, 38. DOI: 10.3969/j.issn.1006-6179.2008.06.009 .
9	NIU D, WEI H J, LIN L, et al. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9[J]. Science, 2017, 357(6357):1303-1307. DOI: 10.1126/science.aan4187 .
10	罕园园, 李娜, 代解杰. 云南省实验动物工作40年发展历程与思考[J]. 实验动物与比较医学, 2021, 41(5): 399-408. DOI: 10.12300/j.issn.1674-5817.2021.136 .
	HAN Y Y, LI N, DAI J J. History and countermeasure discovered from 40-year development of laboratory animals in Yunnan Province[J]. Lab Anim Comp Med, 2021, 41(5): 399-408. DOI: 10.12300/j.issn.1674-5817.2021.136 .
11	YU P, QI F F, XU Y F, et al. Age-related rhesus macaque models of COVID-19[J]. Anim Model Exp Med, 2020, 3(1):93-97. DOI: 10.1002/ame2.12108 .
12	LU N, GU T X, TIAN X L, et al. Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19[J]. Signal Transduct Target Ther, 2022, 7(1):371. DOI: 10.1038/s41392-022-01220-7 .
13	邹弈星, 蒋佳, 王敬东. 四川省实验动物产业发展现状及对策思考[J]. 实验动物科学, 2013, 30(1):42-45. DOI: 10.3969/j.issn.1006-6179.2013.01.012 .
	ZOU Y X, JIANG J, WANG J D. The current situation and countermeasures in laboratory animal industry of Sichuan Province[J]. Lab Anim Sci, 2013, 30(1):42-45. DOI: 10.3969/j.issn.1006-6179.2013.01.012 .
14	陈兵, 邹弈星, 姚凌云, 王敬东. 四川省实验动物管理政策分析[J]. 实验动物与比较医学, 2024, 44(2): 209-213. DOI:10.12300/j.issn.1674-5817.2023.110 .
	CHEN B, ZOU Y X, YAO L Y, et al. Research on management policies of laboratory animals in Sichuan Province[J]. Lab Anim Comp Med, 2024, 44(2): 209-213. DOI:10.12300/j.issn.1674-5817.2023.110 .
15	漆重阳, 陈林, 艾曼, 等. 基于江苏省实验动物行政许可现状的安全管理对策[J]. 实验动物与比较医学, 2023, 43(1):79-85. DOI: 10.12300/j.issn.1674-5817.2022.083 .
	QI C Y, CHEN L, AI M, et al. Safety management countermeasures based on the status of laboratory animal administrative licensing in Jiangsu Province[J]. Lab Anim Comp Med, 2023, 43(1):79-85. DOI: 10.12300/j.issn.1674-5817.2022.083 .
16	魏著英, 窦英杰, 贾彩霞, 等. 屏障设施环境条件对实验动物生长和生理指标的影响[J]. 内蒙古大学学报(自然科学版), 2022, 53(5):555-560. DOI: 10.13484/j.nmgdxxbzk.20220515 .
	WEI Z Y, DOU Y J, JIA C X, et al. Effects of facility environment on experimental animals and animal experiments[J]. J Inn Mong Univ Nat Sci Ed, 2022, 53(5):555-560. DOI: 10.13484/j.nmgdxxbzk.20220515 .
17	巩薇, 贺争鸣, 李根平. 北京市实验动物突发重大事件应急预案的制定[J]. 实验动物科学, 2008, 25(1):29-33. DOI: 10.3969/j.issn.1006-6179.2008.01.009 .
	GONG W, HE Z M, LI G P. Formulation of emergency plan for laboratory animals in Beijing[J]. Lab Anim Sci, 2008, 25(1):29-33. DOI: 10.3969/j.issn.1006-6179.2008.01.009 .
18	陆建玲, 单斌, 孙兴莲, 等. 江苏省突发实验动物生物安全事件应急预案的编制[J]. 实验动物与比较医学, 2015, 35(6): 510-514. DOI: 10.3969/j.issn.1674-5817.2015.06.016 .
	LU J L, SHAN B, SUN X L, et al. Compilation of emergency response plan for sudden biosecurity incidents involving laboratory animals in Jiangsu Province[J]. Lab Anim Comp Med, 2015, 35(6): 510-514. DOI:10.3969/j.issn.1674-5817.2015. 06.016 .
19	褚芳, 黄雪梅, 徐丽英, 等. 江西省实验动物突发重大疫情应急预案的制定[J]. 实验动物科学, 2011, 28(3):55-59. DOI: 10.3969/j.issn.1006-6179.2011.03.014 .
	CHU F, HUANG X M, XU L Y, et al. Formulation of emergency plan for sudden major epidemic situation of experimental animals in Jiangxi Province[J]. Lab Anim Sci, 2011, 28(3):55-59. DOI: 10.3969/j.issn.1006-6179.2011.03.014 .
20	刘美佟, 陈长, 张兆强, 等. 湖南省实验动物机构生物安全管理现状调查[J]. 实验动物与比较医学, 2024, 44(2): 202-208. DOI:10.12300/j.issn.1674-5817.2023.129 .
	LIU M T, CHEN Z, ZHANG Z Q, et al. Investigation on current biosafety management status in laboratory animal institutions in Hunan Province[J]. Lab Anim Comp Med, 2024, 44(2): 202-208. DOI:10.12300/j.issn.1674-5817.2023.129 .

排名 Rank	单位名称 Facility name	实验动物设施面积/㎡ Laboratory animal facility area/㎡
排名 Rank	单位名称 Facility name	普通环境 Conventional environment	屏障环境 Barrier environment	总面积 Total area
1	成都华西海圻医药科技有限公司	33 670	6 474	40 144
2	四川横竖生物科技股份有限公司	39 200	0	39 200
3	四川省医学科学院·四川省人民医院实验动物研究所	23 400	1 920	25 320
4	四川格林豪斯生物科技有限公司	14 300	0	14 300
5	四川大学华西医院	1 250	12 138	13 388
6	雅安普莱美生物科技有限公司	13 067	0	13 067
7	成都药明康德新药开发有限公司	10 514	2 353	12 867
8	成都海枫生物科技有限公司	9 133	2 385	11 518
9	四川维通利华实验动物技术有限公司	0	11 056	11 056
10	成都达硕实验动物有限公司	8 400	1 000	9 400

排名 Rank	单位名称 Facility name	实验动物设施面积/㎡ Laboratory animal facility area/㎡
排名 Rank	单位名称 Facility name	普通环境 Conventional environment	屏障环境 Barrier environment	总面积 Total area
1	成都华西海圻医药科技有限公司	33 670	6 474	40 144
2	四川横竖生物科技股份有限公司	39 200	0	39 200
3	四川省医学科学院·四川省人民医院实验动物研究所	23 400	1 920	25 320
4	四川格林豪斯生物科技有限公司	14 300	0	14 300
5	四川大学华西医院	1 250	12 138	13 388
6	雅安普莱美生物科技有限公司	13 067	0	13 067
7	成都药明康德新药开发有限公司	10 514	2 353	12 867
8	成都海枫生物科技有限公司	9 133	2 385	11 518
9	四川维通利华实验动物技术有限公司	0	11 056	11 056
10	成都达硕实验动物有限公司	8 400	1 000	9 400

序号 Number	单位名称 Facility name	实验动物生产范围 Production scope of laboratory animals	生产能力 Production capacity
1	成都达硕实验动物有限公司	普通级：小型猪、比格犬、豚鼠、兔 SPF级：大鼠、小鼠、豚鼠	>100万只
2	成都药康生物科技有限公司	SPF级：小鼠、大鼠	>100万只
3	成都生物制品研究所有限责任公司	SPF级：小鼠、仓鼠清洁级：豚鼠	>30万只
4	简阳达硕动物科技有限公司	SPF级：大鼠、小鼠	>10万只
5	四川大学	SPF级：大鼠、小鼠	>5万只
6	四川省实验动物专委会养殖场	SPF级：小鼠、大鼠、豚鼠普通级：兔、豚鼠	>5万只

序号 Number	单位名称 Facility name	实验动物生产范围 Production scope of laboratory animals	生产能力 Production capacity
1	成都达硕实验动物有限公司	普通级：小型猪、比格犬、豚鼠、兔 SPF级：大鼠、小鼠、豚鼠	>100万只
2	成都药康生物科技有限公司	SPF级：小鼠、大鼠	>100万只
3	成都生物制品研究所有限责任公司	SPF级：小鼠、仓鼠清洁级：豚鼠	>30万只
4	简阳达硕动物科技有限公司	SPF级：大鼠、小鼠	>10万只
5	四川大学	SPF级：大鼠、小鼠	>5万只
6	四川省实验动物专委会养殖场	SPF级：小鼠、大鼠、豚鼠普通级：兔、豚鼠	>5万只

排名 Rank	单位名称 Facility name	使用实验动物种类 Laboratory animal species used	使用数量/万只 Usage quantity, ×10⁴
1	成都生物制品研究所有限责任公司	仓鼠、小鼠	22.43
2	四川大学	小鼠、大鼠、豚鼠、兔	9.54
3	成都华西海圻医药科技有限公司	小鼠、大鼠、豚鼠、兔、猴、比格犬、小型猪	8.32
4	四川大学华西医院	大鼠、小鼠、犬、实验用猪、实验用羊、兔、猴、豚鼠	6.42
5	西南医科大学	小鼠、大鼠、兔、豚鼠	5.93
6	四川省中医药科学院	小鼠、大鼠、豚鼠、兔	5.07
7	四川科伦药业股份有限公司	猫、兔、豚鼠、小鼠	3.15
8	四川海思科制药有限公司	大鼠、小鼠、兔、豚鼠	3.13
9	四川省药品检验研究院	兔、豚鼠、大鼠、仓鼠、小鼠、犬、猫	2.95
10	成都中医药大学	大鼠、小鼠、兔、豚鼠	2.87