Evolution and Prospects of Laboratory Animal Management: A Case Study of Shanghai's Development in the Past Decade

doi:10.12300/j.issn.1674-5817.2023.134

Abstract

Abstract:

There are differences in historical and cultural beliefs, development history, and levels of technological development among different countries and regions around the world. However, they have all established corresponding laboratory animal management systems that are suitable for their national conditions. In 2001, the Ministry of Science and Technology, together with six other ministries, jointly issued the administrative licensing system for experimental animals, which was an innovative measure in China's specialized management system for experimental animals.The State Administration for Market Regulation and the National Standards Committee, based on the welfare of experimental animals and the needs of scientific research, have formulated a series of national standards for laboratory animals, and the local experimental animal management institutions, experimental animal quality testing unit and professional training base have also been established, which provide a strong guarantee for the rapid and healthy development of experimental animal science. This paper reviews the development of experimental animal management in Shanghai in the past ten years, reflects the evolution of national experimental animal management in recent years, points out the weak links in the development process, and puts forward suggestions for the innovation and development of experimental animal work.

Key words: Laboratory animals, Historical evolution, Work development, Shanghai

CLC Number:

Q95-33

Yong ZHAO. Evolution and Prospects of Laboratory Animal Management: A Case Study of Shanghai's Development in the Past Decade[J]. Laboratory Animal and Comparative Medicine, 2023, 43(5): 492-503. DOI: 10.12300/j.issn.1674-5817.2023.134.

Figures/Tables 3

References 9

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年度^* Year^*	检测单位数量 Number of testing units	不合格单位数量 Number of unqualified units	不合格项数量 Number of unqualified items	不合格项（实验动物级别、品种） Unqualified items (laboratory animal grade/varieties)
2010	11	4	4	小鼠肝炎病毒（清洁级小鼠）、支原体（清洁级SD大鼠）、兔出血症病毒免疫抗体合格率不达标（普通级新西兰兔）、体外寄生虫（普通级豚鼠）
2011	19	8	6	全部蠕虫（清洁级小鼠、大鼠）、仙台病毒（清洁级小鼠）、泰泽病原体（清洁级豚鼠）、绿脓杆菌（SPF级小鼠）、小鼠肝炎病毒（清洁级小鼠）、兔出血症病毒免疫抗体合格率不达标（普通级新西兰兔）
2014	28	6	4	全部蠕虫（SPF级小鼠、清洁级小鼠）、绿脓杆菌（SPF级小鼠）、体外寄生虫（普通级豚鼠）、肺炎克雷伯杆菌（SPF级小鼠）
2015	25	3	3	体外寄生虫（普通级新西兰兔）、全部蠕虫（清洁级SD大鼠）、仙台病毒（清洁级KM小鼠）
2016	25	5	4	狂犬病病毒免疫抗体合格率不达标（普通级犬）、布鲁杆菌（普通级犬）、体外寄生虫（普通级新西兰兔和豚鼠）、嗜肺巴斯德杆菌（SPF级大鼠）
2017	28	3	1	绿脓杆菌（SPF级裸小鼠、大鼠）
2018	27	2	2	嗜肺巴斯德杆菌（SPF级BALB/c和ICR小鼠）、体外寄生虫（普通级豚鼠、兔）
2019	28	3	3	布鲁杆菌（普通级犬）、泰泽病原体（清洁级豚鼠）和仙台病毒（SPF级SCID-BG小鼠、清洁级豚鼠）
2020	23	2	2	B病毒（普通级食蟹猴）、体外寄生虫（普通级新西兰兔）
2021	24	0	0	无
2022	24	3	2	肺炎克雷伯杆菌（SPF级NPSG小鼠和裸小鼠）、绿脓杆菌（BALB/c小鼠）

年度^* Year^*	检测单位数量 Number of testing units	不合格单位数量 Number of unqualified units	不合格项数量 Number of unqualified items	不合格项（实验动物级别、品种） Unqualified items (laboratory animal grade/varieties)
2010	11	4	4	小鼠肝炎病毒（清洁级小鼠）、支原体（清洁级SD大鼠）、兔出血症病毒免疫抗体合格率不达标（普通级新西兰兔）、体外寄生虫（普通级豚鼠）
2011	19	8	6	全部蠕虫（清洁级小鼠、大鼠）、仙台病毒（清洁级小鼠）、泰泽病原体（清洁级豚鼠）、绿脓杆菌（SPF级小鼠）、小鼠肝炎病毒（清洁级小鼠）、兔出血症病毒免疫抗体合格率不达标（普通级新西兰兔）
2014	28	6	4	全部蠕虫（SPF级小鼠、清洁级小鼠）、绿脓杆菌（SPF级小鼠）、体外寄生虫（普通级豚鼠）、肺炎克雷伯杆菌（SPF级小鼠）
2015	25	3	3	体外寄生虫（普通级新西兰兔）、全部蠕虫（清洁级SD大鼠）、仙台病毒（清洁级KM小鼠）
2016	25	5	4	狂犬病病毒免疫抗体合格率不达标（普通级犬）、布鲁杆菌（普通级犬）、体外寄生虫（普通级新西兰兔和豚鼠）、嗜肺巴斯德杆菌（SPF级大鼠）
2017	28	3	1	绿脓杆菌（SPF级裸小鼠、大鼠）
2018	27	2	2	嗜肺巴斯德杆菌（SPF级BALB/c和ICR小鼠）、体外寄生虫（普通级豚鼠、兔）
2019	28	3	3	布鲁杆菌（普通级犬）、泰泽病原体（清洁级豚鼠）和仙台病毒（SPF级SCID-BG小鼠、清洁级豚鼠）
2020	23	2	2	B病毒（普通级食蟹猴）、体外寄生虫（普通级新西兰兔）
2021	24	0	0	无
2022	24	3	2	肺炎克雷伯杆菌（SPF级NPSG小鼠和裸小鼠）、绿脓杆菌（BALB/c小鼠）

年度 Year	实验动物许可证/张 Number of laboratory animals license/piece	使用许可证/张 Use license/piece	生产许可证/张 Production license/piece
2013	163	132	31
2014	166	135	31
2015	173	141	32
2016	166	137	29
2017	161	132	29
2018	168	139	29
2019	174	144	30
2020	188	156	32
2021	192（合并16）	162（合并16）	30
2022	192（合并9）	163（合并9）	29
2023（至9月）	208（设施总量233个）	175（使用设施总量200个）	33

年度 Year	实验动物许可证/张 Number of laboratory animals license/piece	使用许可证/张 Use license/piece	生产许可证/张 Production license/piece
2013	163	132	31
2014	166	135	31
2015	173	141	32
2016	166	137	29
2017	161	132	29
2018	168	139	29
2019	174	144	30
2020	188	156	32
2021	192（合并16）	162（合并16）	30
2022	192（合并9）	163（合并9）	29
2023（至9月）	208（设施总量233个）	175（使用设施总量200个）	33

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