Advances on Research of APOE Gene Function and Related Diseases Models

doi:10.3969/j.issn.1674-5817.2015.03.016

Abstract

Abstract: Apolipoprotein E gene (APOE) is located on human chromosome 19, with 3.7 kb length. Its expression production is an alkaline protein containing arginine. ApoE can take part in lipid transport, storage and excretion, as well as nervous system development and injury repair process. High incidence of atherosclerosis and Alzheimer’s disease occurred in human are related with lipid metabolism dysregulation. Researches on animals in vitro showed that the polymorphism of ApoE is related to coronary heart disease, hyperlipidemia and infarction. Transgenic and gene knock out or mutation animal models can help to know more about the process of lipid metabolism, understand the mechanism of occurrence and development process , and find the potential therapeutic targets of related illnesses. Then more effective solutions for the treatment of human diseases can be provided. This essay briefly summaries the mechanism of some diseases related to APOE genotype and apoE protein, and also researches on the development of these diseases in vitro in animal models.

Key words: Apolipoprotein E (apoE), Diseases models, Transgenic animals, Gene knockout

CLC Number:

Q95-33

JIANG Wei-hua,LI Shan-gang,CHEN Xue-jin. Advances on Research of APOE Gene Function and Related Diseases Models[J]. Laboratory Animal and Comparative Medicine, 2015, 35(3): 249-257. DOI: 10.3969/j.issn.1674-5817.2015.03.016.

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