Abstract: Objective To explore the effect of He Dan tablets on chronic non-alcohol fatty liver disease (NAFLD) induced by high fat emulsion in rat. Methods The NAFLD rats model was made with intragastric administration of high fat emulsion and high glucose solution every day for 4 weeks. Then the model rats were intragastrically administrated with high fat emulsion and high glucose solution in the morning and He Dan tablets, Xuezhikang Capsule and Fenofibrate tablets solution in the afternoon for 4 weeks. At the end of experiment, the concentration of the serum alanine aminotransferase (ALT), triglyceride(TG), total cholesterol (TCH), low density lipoprotein cholesterol ( LDL-C), high density lipoprotein cholesterol (HDL-C) and the contents of reduced glutathione (GSH), malondialdehyde (MDA), TCH, TG in liver, and liver organ coefficient were measured. Results Compared with model group, the concentration of the serum ALT, TCH, LDL were significantly lower and serum HDL-C was significantly higher in 3.53 g/kg, 7.06 g/kg, 14.12 g/kg He Dan tablets groups. Moreover, the serum TG and liver MDA, TCH, TG were significantly reduced in 7.06 g/kg、14.12 g/kg He Dan tablets groups compared with model group. Besides, all the rats were examined with pathologic histology, the dose of 7.06 g/kg, 14.12 g/kg could reduce the hepatocyte swelling, steatosis, necrosis and degree of infiltration of inflammatory cells in chronic NAFLD rats. Conclusion He Dan tablets can improve the related indicators in serum and liver of NAFLD rats, and also can alleviate the hepatocyte swelling, steatosis, necrosis and degree of infiltration of inflammatory cells in NAFLD rats.

Key words: He Dan tablet, Non-alcohol fatty liver disease (NAFLD), Rat