Research Progress in Construction and Application of Diabetes Model in Zebrafish

JIANG Xia; QIAN Haojie; WEI Xun; ZHENG Yuxuan; ZHOU Zhengyu

doi:10.3969/j.issn.1674-5817.2020.06.016

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Laboratory Animal and Comparative Medicine ›› 2020, Vol. 40 ›› Issue (6) : 547-552. DOI: 10.3969/j.issn.1674-5817.2020.06.016

Research Progress in Construction and Application of Diabetes Model in Zebrafish

JIANG Xia¹, QIAN Haojie², WEI Xun¹, ZHENG Yuxuan¹, ZHOU Zhengyu¹

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Abstract

Diabetes mellitus is a group of metabolic disorders, and its pathogenesis has not been fully elucidated. Diabetes mainly includes type 1 diabetes, type 2 diabetes and gestational diabetes. Many animals such as mice, rats, rabbits, mini-pigs and macaques are commonly used as diabetes models. As a model organism, zebrafish (Danio rerio) has been widely used to simulate human disease in many fields, including type 1 and type 2 diabetes mellitus. By searching a large amount of literature, this article summarized the current construction methods of zebrafish models of diabetes and its application progress in order to provide references for its future research and application.

Key words

Diabetes / Zebrafish / Animal model / Type 1 diabetes mellitus / Type 2 diabetes mellitus

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JIANG Xia, QIAN Haojie, WEI Xun, ZHENG Yuxuan, ZHOU Zhengyu. Research Progress in Construction and Application of Diabetes Model in Zebrafish[J]. Laboratory Animal and Comparative Medicine. 2020, 40(6): 547-552 https://doi.org/10.3969/j.issn.1674-5817.2020.06.016

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