Abstract: Objective To establish the model of acute lung injury(ALI) of perfluoroisobutylene (PFIB) inhalation and to study the change of the cell factor in blood and lungs tissue，pathological changes of the lung tissue. Methods The model of acute lung injury was induced by (PFIB) inhalation.The protein concentration in bronchoalveolar lavage fluid (DALF), the liquid volume of lung, and the cell factor of interleukin-1、8、10、18 and TNF-a were assessed. The pathology of lung injury were examined. Rusult (l)In the model rats, the liquid volume of lung, and BALF protein concentration are higher than those of negative group. (2) In the acute lung injury rats of PFIB, the characteristic changes of the interleukin -1、8、10、18 and TNF-a in blood and lungs tissue were deteted; (3) The pathology shows that the changes of pulmonary edema and the inflammayory reaction of ALI. Conclusion The research and exploration on the changes and regularity of ALI induced by PFEB inhalation can provide more information about ALI protection and treatment.

Key words: Perfluoroisobutylene, Acute Lung Injury, Interleukin, TNF-a