Abstract: Due to the complexity of in vivo study for endocrine disruptors (EDs)，biological effects, the related research results are usually incongruity. In the recent years, a detection system with more authority is being gradually set up. Rat model was especially emphasized in this system. This article reviewed the significance of rat model in the study of EDs’ biological effects, and also, the detail methods, mechanism, and evaluation of rat model in these studies.

Key words: Endocrine disruptors, Biological effects, in vivo method, Rat