Abstract: With the development of innovative medicine discovery, various kinds of immunodeficiency mice or severe combined immunodeficiency mice were more widely used in each research institutes. The newly raised problem is that the barrier environment and animal populations of more animal research facilities were contaminated by Corynebacterium bovis (C. bovis). At present, the  C. bovis has not been enrolled into SPF laboratory animal-microbiologic standards in China, although this opportunistic pathogen has great threat to immunodeficiency animals. As rapid spread contamination and extremely difficult elimination of C. bovis, it is an extensive disaster to immunodeficiency animal facilities, and there were no appropriate prevention and elimination solutions in the past. In this paper, based on the research progress and the experience of two animal research facilities in past six years, the feasible strategies to prevent and eliminate C. bovis from barrier facilities were proposed.

Key words: Corynebacterium bovis, Immunodeficiency animal, Laboratory animal facility,