Progress on Methods for Establishing Animal Model of Vaginitis

doi:10.3969/j.issn.1674-5817.2016.04.015

Abstract

Abstract: Vaginitis is the common infectious diseases of the women caused by invasive pathogens, which is often happened after vaginal mucosa or cervical injury (such as childbirth, abortion, surgery, etc.). However, the etiology and pathogenesis of vaginitis is still not entirely clear yet. Using animal models of human diseases to research human diseases is an important mean to clarify the pathogenesis of the disease or drug efficacy. Establishing a stable and reliable animal model of vaginitis is an important method for reseaching the pathogenesis and pathophysiology changes of human vaginitis and have an important role in promoting the development of new drugs and vaccines. There are three types of animal models of vaginitis: bacterial vaginosis, vulvovaginal candidiasis and trichomonas vaginitis according to the type of infection. The animal models of bacterial vaginosis are mainly infected by Gardnerella vaginalis, Neisseria gonorrhoeae, Escherichia coli or Staphylococcus aureus. The animal models of vulvovaginal candidiasis are mainly infected by Candida albicans or Candida glabrata. The animal models of trichomonas vaginitis are mainly infected by Trichomonas vaginalis or Tritrichomonas foetus. Mice, rats, rabbits and non-human primates are mainly selected to prepare animal models of vaginosis. In addition, pig vaginal mucosa and human epithelial cells are also commonly used in the preparation of animal models of vaginosis.

Key words: Vaginitis, Animal model, Preparation method, Progress

CLC Number:

R711Q95-33

LI Dong-dong,PANG Qin-xia,ZHU Min,et al. Progress on Methods for Establishing Animal Model of Vaginitis[J]. Laboratory Animal and Comparative Medicine, 2016, 36(4): 317-322. DOI: 10.3969/j.issn.1674-5817.2016.04.015.

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