Abstract: Objiective To establish an animal model for sleeve gastrectomy in SD rat. Methods Twenty male SD rat were operated with sleeve gastrectomy. Ten male SD rat were operated with laparotomy. The weight of the rats were determined before operation, 1st day post operation and on Fortnightly basis for 16 weeks. Results All rats remained alive in the control group, 13 rats remained alive in the SG group. In the control group，weight gain was achieved obviously after operation， whereas in the SG group, weight gain was achieved until the 2th week. In the SG group, weight gain was significantly lower than in the control group. Gastric dilatation were observed obviously in the SG group (2.02 士 0.20 w 3.02 土 0.52，P＜0.01; 0.91 土 0.10 w 1.58 土 0.35，P＜0.01). Conclusion The SG experimental model established on SD rat was reliable ,and it may be used for study the mechanisms of sleeve gastrectomy.

Key words: Sleeve gastrectomy, Morbid obesity, Animal model