›› 2008, Vol. 28 ›› Issue (6): 390-393.

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Changes in Baroreflex Sensitivity in Middle Pregnant SD Rats

  

  1. 1. Obstetrics & Gynecology Hospital of Fudan University, Shanghai 200011, China; 2. Department of Physiology & Pathophysiology, Shanghai Medical College of Fudan University, Shanghai 200032,China; 3. Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China
  • Received:2008-06-05 Online:2008-06-30 Published:2008-06-30

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Abstract: Objective To determine the changes of cardiovascular autonomic control in unrestrained conscious pregnant SD rats. Method Blood pressure, heart rate and their variabilities were measured in conscious, unstrained rats and middle pregnant rats. BRS of heart rate control(BRSHR) was measured by using a bolus intravenous injection of phenylephrine(5 jug/kg). Results HF of HRV as well as spontaneous BRS and BRShr attenuated (P<0.05) in pregnant SD rats compared with control group. Conclusion BRS reduced and regulating function of vagus decreased in middle pregnant SD rats. Measurement of HRV, BPV and BRS by spectral analysis is credible.

Key words: Baroreflex sensitivity, Heart rate variability, Blood pressure variability