Abstract: The renovascular hypertension animal models were successfully established in rats by using “2-Kidney，1-Clip”method. The plasma A I , the platelet cytosolic free calcium concentration([Ca²⁺]_i) and the platelet aggregation (PAg) rate were measured 8 weeks after the operation (at the stable stage of hypertension). The results showed that the [Ca²⁺]_i and PAg rate increased significantly(P＜0.01) , whereas plasma A I only slightly elevated (P＞0.05). These findings suggest that the abnormality of the intracellular calcium and platelet activity were existing during the sustaining period of hypertension in the 2K1C-RHR.

Key words: "Renovascular hypertension, Platelet cytosolic free calcium concentration, Platelet aggregation, Rat "