›› 1995, Vol. 15 ›› Issue (2): 69-71.
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Abstract: The rat model of perinatal cerebral hypoxia-ischemia was prepared by permanent ligation of right common carotid artery combined with a temporary systemic hypoxic (inhaling 8% O2+92% N2) at 37℃ in 7-day-old SD rats. The relationship between beta-endorphin and encephaledema was observed in the established models. The encephaledema was deteriorated after the injection of beta-endorphin into cerebellomedullary cistern, while it was alleviated by the injection of beta-endorphin antiserum. It is suggested that beta-endorphin might play a role in the formation of encephaledema induced by cerebral hypoxic-ischemic injury in neonatal rats and plethoric beta-endorphin will aggravate encephaledema.
Key words: Beta-endorphin, Antiserum, Neonatal rat, Cerebral hypoxic-ischemia, Encephaledema
LU Xiao-Xin-1, CHEN Xin-Min-1, HONG Xin-Ru-2, WANG Cheng-Hai-2. Effects of Beta-Endorphin and Antiserum on Hypoxic Encephaledema in Neonatal Rats[J]. , 1995, 15(2): 69-71.
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https://www.slarc.org.cn/dwyx/EN/Y1995/V15/I2/69