Molecular Genetical Research of Developmental Language Disorders in Foxp2 Mouse Models

doi:10.3969/j.issn.1674-5817.2019.04.015

Abstract

Abstract: FOXP2 was the first gene discovered to be related to a fairly specific speech and language phenotype, called developmental verbal dyspraxia (DVD). This mechanism discovery opened up a new direction for the research of the relevant neural pathway. FOXP2 showed significantly high conservation of sequence and expression in the neural system of a variety of vertebrates, one typical example was that the expression patterns in human fetal brains were highly similar to those in mice of a comparable embryonic stage. Foxp2 mouse models include knock-out mice, mice that carry the etiological mutations that mirror those of the KE family or other patients, and mice in which the murine Foxp2 gene has been ‘humanized’ by including the two human-specific amino acids. The study of the Foxp2 mouse models was reviewed in this paper from molecular networks, sensory processing and motor skill learning, which aimed to shed light on the genetical mechanism of the language disorders.

Key words: Forkhead box P2 (FOXP2), Developmental verbal dyspraxia (DVD)

CLC Number:

R338
Q189

LI Hui. Molecular Genetical Research of Developmental Language Disorders in Foxp2 Mouse Models[J]. Laboratory Animal and Comparative Medicine, 2019, 39(4): 331-336.

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