Progress of Microtus Fortis in Research and Application of Medical Biology

doi:10.3969/j.issn.1674-5817.2018.01.016

Abstract

Abstract: Microtus fortis which has the characteristics of natural resistance to Schistosoma japonicum,has been developed as a unique model animal for schistosomiasis resistance in China.It can also be used as a model animal for the study of diabetes,ovarian cancer and nonalcoholic fatty liver.In this paper,the classification,distribution,morphology and biological characteristics of Microtus fortis were reviewed,and the progresses of the study on the animal models of schistosomiasis,diabetes,ovarian cancer and nonalcoholic fat were summarized.

Key words: Microtus fortis, Schistosoma japonicum, Laboratory animal

CLC Number:

Q95-33

CAI Shu-mei, FU Zhi-qiang, XIE Jian-yun. Progress of Microtus Fortis in Research and Application of Medical Biology[J]. Laboratory Animal and Comparative Medicine, 2018, 38(1): 72-77.

References

[1] 罗泽珣,陈卫,高武,等.中国动物志[兽纲]第六卷啮齿目(下册),仓鼠科[M].北京:科学出版社,2000:221-232.
[2] 马勇.中国有害啮齿动物分布资料[J].中国农业通报,1986,(6):76-82.
[3] 陈安国,郭聪,王勇,等.东方田鼠的生态学即控制对策.见:张知斌,王祖望.农业重要害鼠的生态学与控制对策[M].北京:海洋出版社,1998:130-152.
[4] 黄文几,陈延熹,温业新.中国啮齿类[M].上海:复旦大学出版社,1995:231-233.
[5] 谭邦杰.哺乳动物分类名录[M].北京:中国医药科技出版社,1992:291.
[6] 吴林,张美文,李波.洞庭湖区东方田鼠的食物组成调查[J].兽类学报,1998,18(4):282-291.
[7] 黎申恺,朱祖林,金壁如,等.东方田鼠对日本血吸虫的不感染性[J].寄生虫学报,1965,2(1):103-105.
[8] 柏熊,王晓东.东方田鼠净化的研究初报[J].上海畜牧兽医通汛,2006(6):33.
[9] 柏熊,王晓东,谢建云.东方田鼠种群的生物净化方法[J].实验动物与比较医学,2011,31(3):215-217.
[10] 刘宗传,何永康,朱刽君,等.东方田鼠血液和血清生化指标的测定[J].实用预防医学,1995,6(3):210.
[11] 潘漪清,谢建云,邵伟娟,等.不同地区东方田鼠染色体数及带型比较[J].中国实验动物学杂志,2002,12(3):147-150.
[12] 俞远京,苏志杰,马亚东,等.诱发性东方田鼠糖尿病动物模型的初步研究[J].湖南畜牧兽医,2003,(4):8-9.
[13] 俞远京,苏志杰,周智君,等.东方田鼠自发上皮性卵巢癌的病理研究[C].桂林:中国实验动物学会第七届学术年会论文集,2006:210-213.
[14] 杨玉琴,冯洁,柏熊,等.东方田鼠非酒精性脂肪肝模型的建立[J].中国实验动物学报,2013,21(2):34-38.
[15] 朱国正,汪英华,雷观愚,等.东方田鼠的实验室饲养及其抗血吸虫感染特性[J].上海实验动物科学,1991,11(4):193-198.
[16] 李浩,何艳燕,林矫矫,等.东方田鼠重复感染日本血吸虫试验初步研究[J].中国兽医寄生虫病,2001,9(3):15-17.
[17] 李浩,何艳燕,林矫矫,等.东方田鼠抗日本血吸虫病现象的观察[J].中国兽医寄生虫病,2000,8(2):12-15.
[18] 王庆林,易新元,曾宪芳,等.东方田鼠感染日本血吸虫后肺和肝的组织细胞反应及虫体的扫描电镜观察[J].中国人兽共患病杂志,2002,18(4):65-67.
[19] 成钢,曾文虎,王京仁,等.室内繁殖东方田鼠感染日本血吸虫的实验研究[J].中国血吸虫病防治杂志,2013,25(3):242-245.
[20] Peng J,Han H,Hong Y,et al.Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum[J].Parasitol Res,2010,107(4):939-946.
[21] 孙军,李浩,王喜乐,等.东方田鼠和小鼠感染日本血吸虫后血清NO的变化以及肝、肺病变的比较[J].中国人兽共患病学报,2006,22(5):433-436.
[22] 邵国艳.东方田鼠抗日本血吸虫病相关机理研究[D].上海:复旦大学,2013.
[23] 俞远京,胡维新,王勇,等.野生东方田鼠实验动物化及种质资源保护的初步研究[J].实验动物科学与理,2003(S1):13-17.
[24] He B,Cai G,Ni Y,et al.Characterization and expression of a novel cystatin gene from Schistosoma japonicum[J].Mol Cell Probes,2011,25(4):186-193.
[25] 刘金明,傅志强,李浩,等.东方田鼠ADCC体外杀伤日本血吸虫童虫效果的初步观察[J].寄生虫与医学昆虫学报,2001,8(4):212-219.
[26] 张新跃,何永康,李毅,等.正常东方田鼠血清及脾细胞体外杀血吸虫童虫作用的初步观察[J].中国血吸虫病防治杂志,2001,13(4):206-208.
[27] 蒋守富,魏梅雄,林矫矫,等.东方田鼠血清被动转移抗日本血吸虫的保护力研究[J].中国寄生虫病防治杂志,2004,17(5):47-49.
[28] Hu Y,Lu W,Shen Y,et al.Immune changes of Schistosoma japonicum infections in various rodent disease models[J].Exp Parasitol,2012,131(2):180-189.
[29] Hu Y,Xu Y,Lu W,et al.Effects of Microtus fortis lymphocytes on Schistosoma japonicum in a bone marrow transplantation model[J].Exp Parasitol,2014,142:27-37.
[30] 何永康,罗新松,喻鑫玲,等.洞庭湖区东方田鼠天然抗日本血吸虫抗体水平的初步研究[J].中国寄生虫学与寄生虫病杂志,1999,17(3):6-8.
[31] 蒋守富,魏梅雄,林矫矫,等.东方田鼠IgG3抗体抗血吸虫病作用研究[J].中国寄生虫学与寄生虫病杂志,2008,26(1):34-36.
[32] 傅志强,刘金明,蒋守富,等.东方田鼠抗日本血吸虫抗体水平检测与分析[J].中国兽医寄生虫病,2001,9(4):8-11.
[33] 邹艳,黄志辉,张祖萍,等.东方田鼠血清识别日本血吸虫各期虫体蛋白组分的特性分析[J].实用预防医学,2009,16(1):20-23.
[34] 张新跃,何永康,李毅,等.东方田鼠感染血吸虫前后血清补体C3,C4水平的动态[J].实用预防医学,2001,8(4):244-245.
[35] 刘金明,傅志强,李浩,等.东方田鼠血清体外杀伤日本血吸虫童虫效果的初步观察[J].中国人兽共患病杂志,2002,18(2):81-83.
[36] 欧阳理,易新元,曾宪芳,等.东方田鼠血清及其不同部分对日本血吸虫童虫的体外杀伤作用[J].中国血吸虫病防治杂志,2003,15(2):98-101.
[37] 成钢,王京仁,王兴平,等.东方田鼠和小鼠感染日本血吸虫后组织与血清蛋白组分差异比较研究[J].中国畜牧兽医,2012,39(7):99-102.
[38] 邬国军,秦志强,罗赛群,等.东方田鼠血清组分对日本血吸虫童虫的体外杀伤力[J].中国寄生虫学与寄生虫病杂志,2005,23(6):404-407.
[39] Li R,Wu GJ,Xiong DH,et al.A Microtus fortis protein,serum albumin,is a novel inhibitor of Schistosoma japonicum schistosomula[J].Mem Inst Oswaldo Cruz,2013,108(7):865-872.
[40] Lambris JD,Ricklin D,Geisbrecht BV.Complement evasion by human pathogens[J].Nat Rev Microbiol,2008,6(2):132-142.
[41] Cestari Idos S,Evans-Osses I,Freitas JC,et al.Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi[J].J Infect Dis,2008,198(9):1276-1283.
[42] 蒋韦斌.利用芯片技术分析不同宿主感染日本血吸虫前后基因的差异性表达[D].上海:上海师范大学,2009.
[43] Hu Y,Sun L,Yuan Z,et al.High throughput data analyses of the immune characteristics of Microtus fortis infected with
Schistosoma japonicum[J].Sci Rep,2017,7(1):11311
[44] Hu Y,Xu Y,Lu W,et al.De novo assembly and transcriptome characterization:novel insights into the natural resistance mechanisms of Microtus fortis against Schistosoma japonicum[J].BMC Genomics,2014,15(1):417.
[45] 邵国艳,冯洁,柏熊,等.东方田鼠感染日本血吸虫后的病理与相关基因表达改变[J].中国实验动物学报,2013,21(2):56-60.
[46] Han H,Peng J,Han Y,et al.Differential expression of microRNAs in the non-permissive schistosome host Microtus fortis under schistosome infection[J].PLoS One,2013,8(12):e85080.
[47] 彭金彪.不同宿主来源日本血吸虫童虫差异表达基因的研究[D].中国农业科学院,2010,3(2):72-74.
[48] 洪炀.日本血吸虫童虫在不同敏感性宿主体内差异表达蛋白的研究[D].南京:南京农业大学,2011.
[49] Hong Y,Zhang M,Yang J,et al.Immunoproteomic analysis of Schistosoma japonicum schistosomulum proteins recognized by immunoglobulin G in the sera of susceptible and non-susceptible hosts[J].J Proteomics,2015,124:25-38.
[50] Cheng G,Gong Q,Gai N,et al.Karyopherin alpha 2 (KPNA2) is associated with the natural resistance to Schistosoma japanicum infection in Microtus fortis[J].Biomed Pharmacother,2011,65(3):230-237.
[51] 冯锐.东方田鼠抗日本血吸虫相关基因E77.43部分编码序列的克隆及多克隆抗体的制备[D].长沙:中南大学,2010.
[52] Gong Q,Cheng G,Qin ZQ,et al.Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection[J].Acta Trop,2010,115(3):220-226.
[53] Hong Y,Han Y,Fu Z,et al.Characterization and expression of the Schistosoma japonicum thioredoxin peroxidase-2 gene[J].J Parasitol,2013,99(1):68-76.
[54] Han H,Peng J,Hong Y,et al.Molecular cloning and characterization of a cyclophilin A homologue from Schistosoma japonicum[J].Parasitol Res,2012,111(2):807-817.
[55] 周智君,俞远京,苏志杰,等.热休克蛋白27、70和90在东方田鼠自发性卵巢癌中的表达[J].中国比较医学杂志,2005,15(4):218-220.