Abstract: Objective To observe the effect of octreotide (OTC) on cerebral ischemia-reperfusion injury in rats and explore the related mechanism. Methods Eighty SD rats were randomly divided into 4 groups which were sham group, middle cerebral artery occlusion (MACO) group, low dosage OCT (OCT-L) and high dosage OCT (OCT-H) group. All the rats were treated with OCT or placebo immediately after establishing the MACO model. Neurologic examination was clinically performed on each rat after reperfusion according to the Longa’s scoring method. The brain tissues were then harvested and tested with triphenyltetrazolium chloride staining. The malondialdehyde (MDA) and superoxide dismutase (SOD) activity of brain was also tested. Results Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume (P<0.05). The activity of MDA were decreased significantly in the OCT treated group than MACO group (P<0.05), but the SOD increased significantly in the OCT-H group than MACO group (P<0.05). Conclusion OCT treatment generated protective effect on cerebral ischemia-reperfusion injury in rats.

Key words: Octreotide(OCT), Ischemia-reperfusion injury, Infarction area, Superoxide dismutase(SOD), Malondialdehyde (MDA)