Effects of Salbutamol on Ventilator-induced Lung Injury in Aged Rats

doi:10.3969/j.issn.1674-5817.2014.04.005

Abstract

Abstract: Objective To investigate the influence of salbutamol in aged rat model of ventilator-induced lung injury (VILI)and its underlying mechanism. Methods Twenty-four healthy male Wistar rats were randomly divided into three groups to receive different ventilation protocols for 4h: normal control group (group 1), VILI without treatment (group 2), VILI treated with salbutamol(group 3). After ventilation, the activity of SOD, XOD and the level of MDA, TNF-á, IL-2, IL-6 and IL-8 in left lung tissue were detected. Lung histopathology was assessed by HE staining and electron microscopic observation. Results After 4h mechanical ventilation, the activity of SOD and XOD in lung tissue was significantly higher in group 3 than those of group 2. The level of MDA, TNF-α, IL-2 and IL-6 in lung tissue was significantly lower in group 3 than those of group 2. Histopathologic findings demonstrated that the destruction of lung tissue in group 2 was more serious than group 3. Conclusion Salbutamol reduced the inflammatory reaction, at the same time improved the various antioxidant activity and microcirculation, thereby reduced pulmonary edema of lung tissue and played certain protective function on ventilator-induced lung injury in aged rats.

Key words: Ventilator-induced lung injury, Aged rats, Salbutamol

CLC Number:

Q95-33

CHEN Mei-lian, LAI Guo-xiang, LIU De-ling, ZHUO Hui-chang. Effects of Salbutamol on Ventilator-induced Lung Injury in Aged Rats[J]. Laboratory Animal and Comparative Medicine, 2014, 34(4): 283-287.

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