Abstract: Objective To investigate differences on immunological function of small bowel between white hair black eye (WHBE) rabbit and Japanese white (JW) rabbit. Methods The weanling and 2 months old male WHBE rabbits and JW rabbits were used with 8 in each group. Two kinds of cell separation mediumsŁ¬ficoll and percoll ,were adopted for the isolation and purification. MTT test was applied to detect the lymphocyte proliferation induced by ConA and LPS. Results The levels of lymphocyte proliferation in small bowel of grown WHBE rabbits were much higher than those of grown JW rabbit. Conclusions Immunological function of lymphocytes in small bowel of grown WHBE Rabbit was much weaker than that of Japanese Rabbits. It may warrant further evaluation as a possible animal for the research of irritable bowel syndrome.

Key words: WHBE Rabbit, Japanese Rabbit, Immunological function