Atrial Fibrillation Model By Pacing Double Surperior Pulmonary Veins

doi:10.3969/j.issn.1674-5817.2013.03.006

Abstract

Abstract: Objective To evaluate the feasibility of double-superior-pulmonary veins (PVs) pacing in building atrial fibrillation(AF) model in canine. Methods After open-chest surgery, two decapolar catheter were implanted outside left- and right- superior PVs in 10 healthy Beagle dogs, rapid pacing (1 200 beat/min) were simultaneously performed for 6 hours. AF inducibility, effective refractory period (ERP) and window of vulnerability (WOV) were measured. Results AF model was successfully built in 8 canines. AF induction rate was 80%. After rapid pacing, a significant decrease and then increase could be found in ERP recording (145.±15.1 vs 130±16.3^* vs 136±11.4^**, ^*P=0.004. ^**P=0.494). After five hours AF inducing, the total atrial fibrillation induce window (? WOV) were increased, as compared with the baseline, but without significant difference (26.7±65.3 vs 20±52.9, P>0.05). While in AF model induced by acetylcholine (0,1,3,6 hours), the time of atrial fibrillation induced were first rising then declining, and this trend and the correlation between the change trend of ERP. Conclusion Double superior PV pacing model can be used in pathogenesis of atrial fibrillation, electrophysiology reconstruction, myocardial reconstruction, molecular biology change clinical research, also can be used for tachycardia sex and part of heart failure cardiomyopathy.

Key words: Pacing, Double surperior pulmonary veins, Atrial fibrillation (af), Animal model, Dog

CLC Number:

Q95-33

CHEN Shi-quan, JIANG Chen-yang, SHENG Xia, HUANG Song-qun, GONG Xin-cheng. Atrial Fibrillation Model By Pacing Double Surperior Pulmonary Veins[J]. Laboratory Animal and Comparative Medicine, 2013, 33(3): 195-199.

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