Abstract: Objective To observe the effects of Anti-aging tablets on special learning memory and free radical metabolism in brain of kidney deficiency mouse. Methods Fifty-four male KM mice were categorized into six groups randomly: normal control group, kidney deficiency group (over-fatigue plus sexual overstrain group), low, middle, high doses of Anti-aging tablets groups and Golden Chamber Pill group. Over-fatigue model could be made by forcing mice to swim and kidney deficiency by colldege effect to induce sexual overstrain in male mice. Anti-aging tablets and Golden Chamber Pill could serve as medication. Changes of weight, water maze special learning and memory test, SOD activity and MDA content of brain were examined in different groups. Results The weight and SOD activity of brain in kidney deficiency group were lower than those in control groups (P<0.05, P<0.01), and the latency period of water maze and MDA content of brain were higher than those in control groups (P<0.01), while the weight and SOD activity of brain were higher in Anti-aging tablets groups and Golden Chamber Pill group (P<0.05,P<0.01), and the latency period of water maze and MDA content of brain were lower in Anti-aging tablets groups and Golden Chamber Pill group (P<0.05, P<0.01), compared with those in kidney deficiency group. Conclusion The Anti-aging tablets could be increased the activity of antioxidant enzymes and suppressed the generation of lipid peroxides, and which could be improved the memory ability of the mice.

Key words: Anti-aging tablets, Kidney deficiency, Learning and memory, Free radical metabolism