Abstract: Objective To evaluate the effect of squalene on body fat and organ weight in male obese rats treated with MSG (Monosodium glutamate). Methods Thirty male Wistar rat were randomly divided into 2 groups,the model of the obesity(n=20) and the control group (n=10) at equivalent volume of saline during the same period. After weaning, the trial groups fed with squalene-containing (1000 mg/kg) diet orally and model group given a regular control diet as the same as negative control group. All rats were euthanized at 22 nd week. The concentration of blood fat and blood serum index were measured. Results Compared with the model control group the blood glucose, cholesterol, triglyceride of the squalene treated group rat were significant lower (P<0.05), LDL-C and HDL-C were lower but no significant differece (P>0.05), and Leptin and testosterone were higher (P<0.05). Conclutions The squalene may counteract increases in body fat, reduce blood glucose, cholesterol, triglyceride, LDL-C and HDL-C, increase Leptin and testosterone in MSG -obese rats.

Key words: Squalene, MSG-Obese Rats, Leptin