Pathological Changes of Multi-organ in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Sheep

doi:10.3969/j.issn.1674-5817.2011.04.004

Abstract

Abstract: Objective To observe the pathological changes of multi-organ in acute respiratory distress syndrome(ARDS). Methods The sheep model of ARDS was established by infusing low dose lipopolysaccharide (LPS) intravenously. The sheep were sacrifised after 72 hours, the organs were collected and fixed by 10% formalin. Routine olefin cut sheets were made and stained by hematine-eosin. Then their pathology changes were observed under light microscope. Results Each organ has pathology change in different degree. The most severe organs of pathology change were lung and kidney, liver and spleen were secondary, but heart was not obvious. Moreover the key features of pathology change in organ were stagnant blood, degeneration and necrosis. Conclusion The multi-organ had pathology changes in different degree in ARDS by LPS inducement and lung was the first target organ that was the easiest impaired.

Key words: Acute Respiratory Distress Syndrome(ARDS), Sheep, Lipopolysaccharide (LPS), Pathological change

CLC Number:

Q95-33

NIU Ting-xian, LUO Xiao-hong, WAN Dong-jun, SHI Zhi-yong, WANG Hong-yi, LU Lu. Pathological Changes of Multi-organ in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Sheep[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 248-251.

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