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25 June 1990, Volume 10 Issue 2

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A New Experimental Animal Model for Quality Testing of Hepatitis B Vaccine—An Experimental Study on the Prevention of HBV Infection in Tree Shrews with Hepatitis B Vaccine

SU Jian-Jia, YANG Chun, HUANG Ding-Rui, HUANG Guo-Hua, YAN Rui-Qi

1990, 10(2):  69-71. 

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10 tree shrews were inoculated with HBV vaccine and 9 of them produced anti-HBs in their sera. After injection of HBV in these vaccinated animals, anti-HBc were not found through out the experimental period but only one of them appeared HBsAg transiently. Contrastly, of the 10 controlled tree shrews which had not been pretreated with HBV vaccine, 5 were positive for HBsAg and 8 for anti-HBc. The infectious rate in the vaccinated group (11.11 %) was significantly lower than that in the controls (80.0%)(P<0.01). The protective rate of HBV vaccine was 88.88%. These results showed that the HBV vaccine seems to prevent the HBV infection in tree shrews, tree shrew may be infected with HBV and as an animal model it can be used for study of the safety, immunogenicity and efficacy of HBV vaccine.